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Seminar : Collagen Scaffolds for Soft Tissue Repair

2017-05-12

Speaker: Professor Serena M. Best
Deputy Head, Department of Materials Science and Metallurgy
University of Cambridge
27 Charles Babbage Road, Cambridge CB3 0FS, UK
 
Date: May 12, 2017 (Friday)
 
Time: 10:00 a.m.
 
Venue: Room 7-37, Haking Wong Building, HKU
 
Biomaterial scaffolds support tissue regeneration and play a key role in repair strategies for the human body. With the move from tissue repair- to cell-mediated tissue reconstruction and regeneration, there is an increasing need for the design of appropriate scaffolds to deliver these cells to diseased or injured tissue. This talk will highlight our current understanding of a number
of variables in the design of three dimensional porous architectures to ensure optimised cell infiltration and attachment. Our material of choice is collagen, a highly versatile and bioactive natural macromolecule. The importance of pore structure and morphology have begun to be understood for soft tissue applications, but the nature of the pore interconnections is not always
considered in sufficient detail. Understanding of the physics behind the production of lyophilised porous collagen scaffolds through ice crystal formation has allowed the design of processing conditions for a range of pore morphologies to mimic natural tissue and encourage cell migration. Choice of scaffold biochemistry also allows us to balance scaffold "activity"and mechanical performance. This talk will cover the recent work that has been undertaken to optimise the structure and properties of scaffolds for a range of clinical applications in soft tissue repair.
 
ALL INTERESTED ARE WELCOME.
 
For further information, please contact Prof. Min Wang at 3917 7903.